Premium
Hemoglobin Roseau‐Pointe a Pitre α 2 β 2 90 (F6) Glu → Gly: a new hemoglobin variant with slight instability and low oxygen affinity
Author(s) -
Merault G.,
Keclard L.,
Saint-Martin C.,
Jasmin K.,
Campier A.,
Delanoe-Garin J.,
Arous N.,
Fortune R.,
Theodore M.,
Seytor S.,
Rosa J.,
Blouquit Y.,
Galacteros F.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80642-6
Subject(s) - hemoglobin , oxygen , hemoglobin variants , chemistry , hemoglobin s , instability , biochemistry , cell , physics , organic chemistry , sickle cell anemia , mechanics
A Dominican neonate carrying a new abnormal hemoglobin, hemoglobin Roseau Pointe‐à‐Pitre α 2 β 2 90 (F6) Glu → Gly, was detected in Guadeloupe during application of a cord blood screening program. This variant behaved in isoelectrofocusing as an Hb D, and displayed instability and low whole blood oxygen affinity. In the affected family it was present, either isolated, or in association with a β + thalassemia trait.