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Product of extracellular‐superoxide dismutase catalysis
Author(s) -
Marklund Stefan L.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80613-x
Subject(s) - superoxide , superoxide dismutase , hydrogen peroxide , chemistry , xanthine oxidase , reactive oxygen species , extracellular , xanthine , hydroxyl radical , catalysis , biochemistry , photochemistry , radical , enzyme
Extracellular‐superoxide dismutase is a tetrameric enzyme containing four copper atoms. It has previously been shown to catalyse the decay of the Superoxide radical, but the resulting product was not determined. In a xanthine oxidase‐xanthine system in which about 30% of the electron flux resulted in Superoxide radical formation, accumulation of hydrogen peroxide was determined. Catalysis of Superoxide radical decay by extracellular‐superoxide dismutase was found to result in hydrogen peroxide formation. The catalysed reaction is thus identical to those of previously investigated Superoxide dismutases. Human manganese superoxide dismutase was also found to dismute the Superoxide radical to hydrogen peroxide and water.