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Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa‐2 cell line
Author(s) -
Hierowski Marion T.,
Liebow Charles,
du Sapin Karen,
Schally Andrew V.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80529-9
Subject(s) - dephosphorylation , somatostatin , stimulation , chemistry , pancreatic cancer , endocrinology , medicine , microbiology and biotechnology , cell culture , phosphorylation , cancer research , biology , biochemistry , cancer , genetics , phosphatase
A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa‐2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl‐membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.