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Presence of helodermin‐like peptides of the VIP‐secretin family in mammalian salivary glands and saliva
Author(s) -
Robberecht Patrick,
de Neef Philippe,
Vandermeers André,
Vandermeers-Piret Marie-Claire,
Svoboda Michal,
Meuris Sylvian,
de Graef Jacques,
Woussen-Colle Marie-Claire,
Yanaihara Chizuko,
Yanaihara Noboru,
Christophe Jean
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80445-2
Subject(s) - saliva , secretin , secretin family , salivary gland , salivary proteins , chemistry , medicine , endocrinology , peptide , biochemistry , biology , vasoactive intestinal peptide , neuropeptide , secretion , receptor
Helodermin is a biologically active peptide isolated from the venom of the Gila monster lizard ( Heloderma suspectum ) whose structure is related to that of vasoactive intestinal peptide and secretin. Using a specific radioimmunoassay based on antisera prepared by immunizing rabbits with natural helodermin, we demonstrated the presence of helodermin‐like material in mammalian salivary glands, including parotid, submaxillary and sublingual glands from rat and dog, and parotid and submaxillary glands from man. All helodermin‐like materials had an apparent molecular mass of 4–12 kDa. Dog saliva, collected after pilocarpine stimulation, revealed similar immunoreactivity with a major component around 6 kDa.