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Differential effects of the K + channel blockers apamin and quinine on glucose‐induced electrical activity in pancreatic β‐cells from a strain of ob/ob (obese) mice
Author(s) -
Rosario Luis M.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80391-4
Subject(s) - apamin , quinine , medicine , endocrinology , pancreatic islets , chemistry , differential effects , potassium channel , insulin , islet , immunology , malaria
The effects of apamin and quinine on glucose‐induced electrical activity in pancreatic islets from ob/ob mice (Norwich colony) were compared. Apamin (40–400 nM) increased the duration of the bursts of electrical activity, whereas quinine (50–100 μM) affected only slightly the steady‐state electrical response to glucose. This sensitivity to apamin and poor response to quinine contrast with the resistance to apamin and sensitivity to quinine previously reported for pancreatic islets from albino mice. The results give further support to the idea that pancreatic β‐cells from ob/ob mice have a modified Ca 2+ ‐activated K + permeability.