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Poly ADP‐ribosylation ‐ A cellular emergency reaction?
Author(s) -
Wintersberger Ulrike,
Wintersberger Erhard
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80369-0
Subject(s) - adp ribosylation , nad+ kinase , poly adp ribose polymerase , chemistry , dna , ribose , dna damage , dna repair , biochemistry , microbiology and biotechnology , enzyme , biophysics , biology , polymerase
We propose that the activation of poly(ADP‐ribose) synthetase by DNA damage serves to decrease rapidly and transiently the cellular level of NAD (by production therefrom of poly ADP‐ribose). The result is a slow‐down of energy‐requiring reactions, in particular of replicative DNA synthesis giving cells more time to repair the damage. We do not attribute any specific role to poly ADP‐ribosylated proteins in this reaction beyond their action as acceptors for poly ADP‐ribose