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A → Z transition in the synthetic hexanucleotide (dCdGfl) 3
Author(s) -
Fazakerley G.V.,
Uesugi S.,
Izumi A.,
Ikehara M.,
Guschlbauer W.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80334-3
Subject(s) - transition (genetics) , chemistry , computational biology , biology , biochemistry , gene
500 MHz proton NMR and NOE measurements on (dCdGfl) 3 show that at very low ionic strength the hexanucleotide adopts an A‐DNA conformation, whereas at high salt concentrations a Z‐form is found. At intermediate salt concentrations the two species are in slow exchange on the proton NMR time scale. This transition was also observed by characteristic changes in the CD spectra.