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Human plasma kininogens are identical with α‐cysteine proteinase inhibitors
Author(s) -
Müller-Esterl Werner,
Fritz Hans,
Machleidt Werner,
Ritonja Anka,
Brzin Joze,
Kotnik Matjaz,
Turk Vito,
Kellermann Josef,
Lottspeich Friedrich
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80322-7
Subject(s) - cysteine proteinase inhibitors , kininogen , papain , cysteine , biochemistry , chemistry , serine proteinase inhibitors , peptide sequence , cathepsin , proteinase 3 , microbiology and biotechnology , serine , enzyme , kallikrein , biology , antibody , serine protease , protease , autoantibody , apoptosis , programmed cell death , gene , caspase , immunology
Human high‐ and low‐ M r kininogens were shown to be potent inhibitors of cysteine proteinases such as cathepsin L and papain ( K i = 17–48 pM). A strong immunological cross‐reaction between the kininogens and low‐ M r α‐cysteine proteinase inhibitor from human plasma was found. Comparison of partial amino acid sequences from high‐ and low‐ M r kininogen and low‐ M r α‐cysteine proteinase inhibitor demonstrated sequence identity for all segments analyzed. These findings suggest that the kininogens and the α‐cysteine proteinase inhibitors from human plasma are identical proteins.