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Gene expression in the polycistronic operons of Escherichia coli heat‐labile toxin and cholera toxin: a new model of translational control
Author(s) -
Yamamoto Tatsuo,
Suyama Akira,
Mori Nozomu,
Yokota Takeshi,
Wada Akiyoshi
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80296-9
Subject(s) - cistron , toxin , cholera toxin , escherichia coli , ribosomal binding site , messenger rna , operon , translation (biology) , biology , ribosome , shiga toxin , gene , terminator (solar) , microbiology and biotechnology , genetics , rna , physics , ionosphere , astronomy
A new model is proposed based on the suggestion that stable local secondary structures of mRNA interfere with ribosome movement on mRNA and consequently reduce the translation rate. This model accounts for a different level of translation for each cistron in the polycistronic mRNA of Escherichia coli heat‐labile toxin (LT) and cholera toxin. We also conclude that the mRNA secondary structures have been conserved during the evolution of the toxin genes for its functional importance.