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Effect of dexamethasone on polypeptides synthesised in polymorphonuclear leucocytes
Author(s) -
Blowers L.E.,
Jayson M.I.V.,
Jasani M.K.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80293-3
Subject(s) - dexamethasone , methionine , chemistry , peripheral blood , glucocorticoid , gel electrophoresis , electrophoresis , medicine , endocrinology , biochemistry , microbiology and biotechnology , biology , amino acid
The effect of a glucocorticoid on protein synthesis in human polymorphonuclear leucocytes (PMNLs) was investigated by two‐dimensional gel electrophoresis. In the peripheral blood PMNLs of healthy laboratory personnel, the rate of incorporation of L 35 S]methionine into a least nine polypeptides was consistently influenced by dexamethasone in a dose‐dependent manner, being increased in the case of seven polypeptides and decreased in the remainder.