Premium
A triple helix model for the structure of chromatin fiber
Author(s) -
Makarov V.,
Dimitrov S.,
Smirnov V.,
Pashev I.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80292-1
Subject(s) - triple helix , collagen helix , chromatin , biophysics , chemistry , microbiology and biotechnology , biology , stereochemistry , biochemistry , dna
A model of chromatin fiber structure is presented in which a repeating unit of a trinucleosome forms a 3‐dimensional zigzag. Twisting and compression of the zigzag result in a triple helix structure. The model is built mainly on the flow linear dichroism data showing that (a) nucleosomal disc faces are tilted relative to the fiber axis, (b) the orientation of nucleosomes does not change upon folding and unfolding of chromatin, and (c) the orientation of nucleosomes is maintained by the globular domain of histone HI.