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Protective effect of the flavonoid silybin dihemisuccinate on the toxicity of phenylhydrazine on rat liver
Author(s) -
Valenzuela Alfonso,
Guerra Ricardo
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80278-7
Subject(s) - phenylhydrazine , lipid peroxidation , flavonoid , chemistry , glutathione , pharmacology , antioxidant , biochemistry , mechanism of action , toxicity , in vivo , radical , in vitro , biology , organic chemistry , enzyme , microbiology and biotechnology
Phenylhydrazine is a hemolytic agent whose mechanism of action is related with the formation of free radicals and the induction of lipid peroxidation. The flavonoid silybin dihemisuccinate is an antihepatotoxic principle used in the treatment of many liver diseases; its mechanism of action has been ascribed to its antioxidant properties. This work demonstrates, using a hemoglobin‐free perfusion system, the protective effect of the in vivo treatment of the rat with silybin dihemisuccinate on the hepatic glutathione depletion and lipid peroxidation induced by the infusion of phenylhydrazine into the perfusion buffer.