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Inhibitors for distinction of three types of human glutathione transferase
Author(s) -
Kalim Tahir Mohammad,
Guthenberg Claes,
Mannervik Bengt
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80269-6
Subject(s) - transferase , glutathione s transferase , glutathione transferase , chemistry , biochemistry , glutathione , cytosol , enzyme
A set of inhibitors that are useful for distinction of three types of human cytosolic glutathione transferase is presented. The near‐neutral transferase is inhibited most effectively by Cibacron blue (itI 50 = 0.05 μM), the acidic transferase by Cibacron blue (itI 50 = 0.5 μM), and the basic transferase by tributyltin acetate (itI 50 = 0.1 μM). The use of any of these two compounds makes possible differentiation between all three types of human transferase.