Premium
Vasopressin inhibits cyclic AMP accumulation and adenylate cyclase activity in cerebral preparations
Author(s) -
Newman Michael E.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80260-x
Subject(s) - adenylate kinase , forskolin , vasopressin , cyclase , medicine , endocrinology , cerebral cortex , chemistry , hippocampal formation , arginine , biology , biochemistry , enzyme , stimulation , amino acid
Arginine‐vasopressin (AVP) and lysine vasopressin (LVP) elicited a dose‐dependent inhibition of noradrenaline‐sensitive cyclic AMP accumulation in rat cerebral cortical slices, and of forskolin‐stimulated adenylate cyclase activity in a rat cerebral cortical membrane preparation. In both cases LVP was more potent than AVP, and exerted half‐maximal effects at concentrations similar to those found effective in binding studies on rat hippocampal membranes. In hippocampal slices, AVP did not affect, cyclic AMP accumulation at low concentrations but potentiated the effect of noradrenaline at higher concentrations. In caudate membranes, AVP inhibited dopamine‐stimulated adenylate cyclase with a similar dose‐dependency to that seen for forskolin activation in cortex membranes.