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Pulse‐radiolysis study of daunorubicin redox cycles
Author(s) -
Houée-Levin C.,
Gardès-Albert M.,
Ferradini C.,
Faraggi M.,
Klapper M.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80188-5
Subject(s) - semiquinone , radiolysis , hydroquinone , chemistry , daunorubicin , disproportionation , radical , photochemistry , kinetics , aqueous solution , redox , inorganic chemistry , organic chemistry , medicine , physics , quantum mechanics , leukemia , catalysis
Daunorubicin aqueous solutions were reduced by COO .−1 or e aq −1 free radicals produced by pulse radiolysis. The kinetics of the semiquinone radical formation and decay were studied. The semiquinone disproportionation leads to a pseudo‐equilibrium between the drug, its semiquinone and hydroquinone reduced states ( K eq = 30 at pH 7), which lasts a few hunderd milliseconds and which is destroyed by the hydroquinone glycosidic cleavage. Consequences concerning daunorubicin antitumour action are briefly discussed.