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Effects of growth hormone‐releasing factor and somatostatin on growth hormone secretion and cellular cyclic AMP levels
Author(s) -
Law Greg J.,
Ray Keith P.,
Wallis Michael
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80180-0
Subject(s) - somatostatin , medicine , endocrinology , secretion , growth hormone–releasing hormone , basal (medicine) , intracellular , anterior pituitary , chemistry , hormone , somatotropic cell , pituitary gland , growth hormone , biology , biochemistry , insulin
Human pancreatic growth hormone‐releasing factor (GRF‐44‐NH 2 ) stimulated growth hormone (GH) secretion and intracellular cyclic AMP levels in cultured pituitary cells from both sheep and rat. Somatostatin (SRIF), over a wide range of doses and time, showed no significant effect on the elevated cyclic AMP levels in sheep cells, but did block the GH release in a dose‐dependent manner. In rat cells, however, SRIF inhibited GRF‐stimulated cyclic AMP levels by 75% maximum (still 8‐fold greater than the basal levels) and GH release to almost half the basal value. We conclude that somatostatin inhibits GRF‐elevated cyclic AMP levels in rat pituitary cells but not in sheep cells.