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1,4‐Thiomorpholine‐3,5‐dicarboxylic acid, a novel cyclic imino acid detected in bovine brain
Author(s) -
Cavallini D.,
Matarese R.M.,
Pecci L.,
Ricci G.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80117-4
Subject(s) - lanthionine , chemistry , dicarboxylic acid , amino acid analysis , amino acid , chromatography , biochemistry
Gas‐liquid chromatography of enriched bovine brain extract revealed the occurrence of several sulfur‐containing compounds. By co‐chromatography with authentic product and by mass‐spectrometric analysis, one of these compounds has been identified as 1,4‐thiomorpholine‐3,5‐dicarboxylic acid (TMDA). The possible derivation of TMDA from lanthionine is discussed. This represents the second S‐containing cyclic imino acid so far discovered in a mammalian brain whose physiological significance has not yet been explored.