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Specific inhibition of mitochondrial protein synthesis influences the amount of complex I in mitochondria of rat liver and Neurospora crassa directly
Author(s) -
van den Bogert C.,
Holtrop M.,
de Vries H.,
Kroon A.M.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80112-5
Subject(s) - neurospora crassa , mitochondrion , neurospora , crassa , mitochondrial dna , biochemistry , biology , protein biosynthesis , gene , microbiology and biotechnology , mutant
Specific inhibition of mitochondrial protein synthesis reduces the oxidation rate of NADH‐linked substrates in rat liver as well as in Neurospora crassa mitochondria. The present study shows that this is due to the fact that inhibition of mitochondrial protein synthesis leads to a decrease of the concentration of active complex I. Therefore, these results demonstrate that at least one of the genes for the subunits of complex I is localized on mitochondrial DNA.