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Modification of acyl‐plasmin‐streptokinase complex with polyethylene glycol
Author(s) -
Tomiya Noboru,
Watanabe Kazuo,
Awaya Juichi,
Kurono Masayasu,
Fujii Setsuro
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80076-4
Subject(s) - streptokinase , plasmin , polyethylene glycol , chemistry , antibody , protease , neutralization , biochemistry , enzyme , medicine , immunology , myocardial infarction
Acyl‐plasmin‐streptokinase complex has advantages as a ‘site’ directed fibrinolytic agent with the active site protected from the plasma protease inhibitors. But, in clinical use, the fibrinolytic potential of this acylenzyme complex is modified or abolished by the presence of streptokinase antibodies in the patients. Therefore, better therapeutic agents are required. In this work, chemical modification of the acyl‐plasmin‐streptokinase complex with polyethylene glycol was found to result in marked resistance to neutralization with streptokinase antibodies.