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High enkephalyl peptide degradation, due to angiotensin‐converting enzyme‐like activity in human CSF
Author(s) -
Lantz I.,
Terenius L.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80073-9
Subject(s) - enzyme , chemistry , enkephalin , peptide , angiotensin converting enzyme , biochemistry , renin–angiotensin system , aminopeptidase , metabolism , endocrinology , biology , receptor , amino acid , leucine , opioid , blood pressure
The metabolism of enkephalin peptides was studied in human cerebrospinal fluid. The degradation rates of (Leu)‐enkephalin and (Leu)‐enkephalin‐Arg 6 were compared and the latter was degraded at a 10‐fold higher rate. The major enzyme activity was investigated by M r determination and inhibition experiments, showing marked similarity with angiotensin‐converting enzyme.