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Glyceraldehyde‐3‐phosphate dehydrogenase is one of the three major RNA‐binding proteins of rabbit reticulocytes
Author(s) -
Ryazanov Alexei G.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80058-2
Subject(s) - glyceraldehyde 3 phosphate dehydrogenase , rabbit (cipher) , chemistry , biochemistry , dehydrogenase , rna , glyceraldehyde , microbiology and biotechnology , biology , enzyme , gene , statistics , mathematics
One of the 3 major RNA‐binding proteins of rabbit reticulocytes, a polypeptide of 36 kDa, is identified as glyceraldehyde‐3‐phosphate dehydrogenase (GAPD). This fact was deduced from the identity of molecular masses, one‐dimensional peptide maps and isoelectric points of the 36 kDa protein and GAPD from rabbit muscle. It is concluded that GAPD can bind rather unspecifically different RNAs and polynucleotides. This means that GAPD, like other RNA‐binding proteins, can form loose dynamic complexes with polyribosomes. Association of such a kind may be used for compartmentation of glycolysis near polyribosomes.