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A new hemoglobin variant, Hb Mito [β144(HC 1)Lys → Glu], with increased oxygen affinity
Author(s) -
Harano Keiko,
Harano Teruo,
Ueda Satoshi,
Ohkushi Toshihiro,
Imai Kiyohiro
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80046-6
Subject(s) - hemoglobin , bohr effect , chemistry , oxygen , hemoglobin variants , amino acid substitution , phosphate , biochemistry , stereochemistry , mutation , oxygen–haemoglobin dissociation curve , organic chemistry , gene
A new abnormal hemoglobin, Hb Mito [β144(HC 1)Lys → Glu], with an amino acid substitution in the 2,3‐DPG pocket, was discovered in a Japanese female. This hemoglobin showed increased oxygen affinity, and decreased organic phosphate and Bohr effects, while the Hill constant n was normal.