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Kainate‐induced uptake of calcium by synaptosomes from rat brain
Author(s) -
Pastuszko Anna,
Wilson David F.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80043-0
Subject(s) - kainate receptor , calcium , chemistry , biophysics , neuroscience , pharmacology , biochemistry , glutamate receptor , medicine , biology , ampa receptor , organic chemistry , receptor
Kainic acid induces a rapid increase in 45 Ca 2+ uptake by crude synaptosomal fractions isolated from rat brain. This enhanced Ca 2+ permeability occurs with a half‐time of approx. 1 s, similar to the fast phase of depolarization‐induced calcium uptake. The depolarization‐induced uptake of calcium is inhibited 85% by 3 mM CoCl 2 80% by 100μM quinacrine and 50% by 15μM trifluoperazine while these agents had little effect on the kainate‐induced uptake. It is proposed that kainate induces receptor‐mediated opening of a class of calcium channels with properties different from those of the voltage‐dependent channels.