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Myeloperoxidase oxidation of sulfur‐centered and benzoic acid hydroxyl radical scavengers
Author(s) -
Green Terrence R.,
Fellman Jack H.,
Eicher Alisa L.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80037-5
Subject(s) - chemistry , benzoic acid , hydroxyl radical , sulfur , myeloperoxidase , radical , photochemistry , hypochlorous acid , organic chemistry , medicine , inflammation
Myeloperoxidase (MPO) oxidizes sulfur‐centered and benzoate hydroxyl radical scavengers through formation of HOCl. Sulfur‐centered hydroxyl radical scavengers compete with benzoate as antioxidants ofHOCl. We conclude from these observations that competition experiments between benzoate and sulfur‐centered hydroxyl radical scavengers are not sufficiently specific to infer participation of hydroxyl radicals in oxidative reactions mediated by neutrophils because of the unique action of MPO in affecting oxidation of the test radical scavengers.