Premium
Channeling of ammonia from glutaminase to carbamoyl‐phosphate synthetase in liver mitochondria
Author(s) -
Meijer Alfred J.
Publication year - 1985
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(85)80018-1
Subject(s) - carbamoyl phosphate synthetase , glutaminase , ammonia , mitochondrion , citrulline , biochemistry , glutamine synthetase , chemistry , glutamine , phosphate , enzyme , arginine , amino acid
In isolated rat‐liver mitochondria the rate of citrulline synthesis from glutamine does not respond to changes in the ammonia concentration in the extramitochondrial fluid. This suggest that ammonia, produced in the mitochondria via glutaminase, is directly channeled to carbamoyl‐phosphate synthetase.