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The gramicidin A channel
Author(s) -
Etchebest Catherine,
Pullman Alberte
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81397-6
Subject(s) - computation , channel (broadcasting) , chain (unit) , chemistry , energy profile , occupancy , gramicidin , center (category theory) , flexibility (engineering) , crystallography , stereochemistry , physics , energy (signal processing) , mathematics , computer science , telecommunications , algorithm , biochemistry , engineering , quantum mechanics , statistics , architectural engineering , membrane
The inclusion of the presence and flexibility of the CH 2 CH 2 OH end chain in the computation of the energy profile for single occupancy by Na + of the gramicidin A channel modifies substantially the profile obtained without that chain. The binding site (deepest minimum) in the profile is situated at 10.5 Å from the center of the channel, in satisfactory agreement with the conclusions based on 13 C‐NMR studies. The existence of an external minimum at the mouth is confirmed.