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Subcellular distribution of acetylcholinesterase asymmetric forms during postnatal development of mammalian skeletal muscle
Author(s) -
Fernandez Hugo L.,
Seiter Thomas C.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81388-5
Subject(s) - acetylcholinesterase , skeletal muscle , chemistry , microbiology and biotechnology , distribution (mathematics) , tissue distribution , biochemistry , anatomy , medicine , biology , enzyme , mathematics , mathematical analysis
This study describes the changes which occur in intra‐ and extracellular asymmetric acetylcholinesterase (AChE) forms in rat gracilis muscle during postnatal development. Initially (day 7) these forms (12.5 S and 16 S AChE) were evenly distributed along the muscle and only present intracellularly. With advancing age (days 7–28) they gradually became concentrated in endplate ( vs non‐endplate) muscle regions where a certain proportion of them was subsequently externalized. In contrast, no externalization was observed in the non‐endplate regions. Our results support the view that AChE asymmetric forms are assembled within the muscle cell prior to their deposition on the extracellular synaptic compartment.