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Cyclic AMP and anaerobic gene expression in E. coli
Author(s) -
Unden Gottfried,
Guest John R.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81336-8
Subject(s) - adenylate kinase , cyclase , activator (genetics) , escherichia coli , fumarate reductase , effector , biochemistry , chemistry , gene , gene expression , anaerobic exercise , microbiology and biotechnology , biology , receptor , physiology
The expression of the fumarate reductase system of Escherichia coli is completely dependent on the presence of adenylate cyclase or cyclic AMP, but the cyclic AMP receptor protein (CRP) is not required. This suggests that cyclic AMP may function as an effector for a second gene activator protein, possibly Fnr, and thus form part of a redox‐sensitive regulatory mechanism controlling the expression of anaerobic respiratory functions.