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The effect of lipopolysaccharide on lipid bilayer permeability of β‐lactam antibiotics
Author(s) -
Hiruma Ryoichi,
Yamaguchi Akihito,
Sawai Tetsuo
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81326-5
Subject(s) - lipopolysaccharide , liposome , chemistry , permeability (electromagnetism) , lipid bilayer , cephalosporin , bilayer , permeation , polysaccharide , lipid a , biophysics , bacterial outer membrane , membrane , chromatography , antibiotics , biochemistry , biology , immunology , escherichia coli , gene
The lipid‐bilayer permeability of cephalosporins was extensively suppressed by addition of lipopolysaccharide to liposomal membrane in proportion to the hydrophobicity of the drugs. This suggests that the polysaccharide chain layer contributes to the barrier function. The importance of the polysaccharide chain in the barrier function was also supported by the fact that the permeability to Rd‐type lipopolysaccharide‐containing liposomes showed essentially the same dependency on the hydrophobicity of the cephalosporins as that of the lipopolysaccharide‐free liposomes. In this case the permeability of the cephalosporins was proportional to their hydrophobicity. Similar lipopolysaccharide effect was also observed in the permeation of penicillins.