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Three‐dimensional structure of monoanionic methionine‐enkephalin: X‐ray structure of tert ‐butyloxycarbonyl‐Tyr‐Gly‐Gly‐(4‐bromo)Phe‐Met‐OH
Author(s) -
Doi Mitsunobu,
Ishida Toshimasa,
Inoue Masatoshi,
Fujiwara Takaji,
Tomita Ken-ichi,
Kimura Terutoshi,
Sakakibara Shunpei
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81318-6
Subject(s) - chemistry , dimer , hydrogen bond , enkephalin , stereochemistry , molecule , intermolecular force , residue (chemistry) , crystal structure , x ray , methionine , derivative (finance) , crystallography , receptor , amino acid , biochemistry , organic chemistry , opioid , physics , quantum mechanics , financial economics , economics
The conformation of tert ‐butyloxycarbonyl‐Tyr‐Gly‐Gly‐(4‐bromo)Phe‐Met‐OH, as a monoanionic derivative of Met‐enkephalin, was elucidated by X‐ray crystal analysis. The molecule took an extended conformation which was bended at the Phe residue. The implication of the dimer formation caused by 4 intermolecular hydrogen bonds was discussed in the relation with the opiate receptor.