Premium
Involvement of protein HMG1 in DNA replication
Author(s) -
Alexandrova Evdokia A.,
Marekov Lyuben N.,
Beltchev Beltcho G.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81260-0
Subject(s) - replication (statistics) , dna replication , chemistry , dna , ter protein , microbiology and biotechnology , biophysics , computational biology , origin of replication , biology , biochemistry , virology
Antibodies against HMG1 inhibit the incorporation of [ 3 H]thymidine in Ehrlich ascites cell nuclei. By the use of specific inhibitors it is shown that HMG1 is needed for the action of the replicative DNA polymerase and not for the reparative one. This is supported by the fact that the addition of exogenous HMG1 to the nuclei enhances the replication process.