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Inhibition by Cu 2+ of amphotericin B induced lysis of erythrocytes
Author(s) -
Chéron Monique,
Bolard Jacques,
Brajtburg Janina
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81255-7
Subject(s) - lysis , amphotericin b , chemistry , circular dichroism , biochemistry , biophysics , microbiology and biotechnology , biology , antifungal
Amphotericin B‐induced lysis of erythrocytes is diminished in the presence of Cu 2+ , but the prelytic amphotericin B‐induced K + leakage is unaffected. These results and the weak binding of Cu 2+ to amphotericin B, demonstrated by circular dichroism and EPR studies, are consistent with the view that Cu 2+ protects erythrocytes by increasing their resistance to lysis.