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Chemically induced antioxidant‐sensitive respiration
Author(s) -
Videla Luis A.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81253-3
Subject(s) - phenylhydrazine , antioxidant , malondialdehyde , glutathione , chemistry , respiration , biochemistry , xanthine , in vivo , ethanol , pharmacology , biology , enzyme , medicinal chemistry , botany , microbiology and biotechnology
The interrelations between the hepatic chemically induced antioxidant‐sensitive respiration and the contents of malondialdehyde (MDA) and of reduced glutathione (GSH), were studied in the isolated hemoglobin‐free perfused rat liver. Antioxidant‐sensitive respiration was induced by the infusion of agents such as ethanol, iron, xanthine or t ‐butyl hydroperoxide, or by phenylhydrazine pretreatment in vivo. The development of this respiratory component occurred concomitantly with high levels of MDA in the perfused livers, while those of GSH were diminished.