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Specific interactions of liposomes with PMN leukocytes upon incorporating tuftsin in their bilayers
Author(s) -
Singhal Arun,
Bali Anu,
Jain Rakesh K.,
Gupta C.M.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81251-x
Subject(s) - tuftsin , liposome , chemistry , biophysics , microbiology and biotechnology , biochemistry , biology , peptide
Incorporation of tuftsin derivatives, Thr‐Lys‐Pro‐Arg‐NH‐C 18 H 37 or Thr‐Lys‐Pro‐Arg‐NH‐(CH 2 ) 2 ‐NH‐COC 15 H 31 , into an egg phosphatidylcholine/cholesterol liposome bilayer led to significantly enhanced binding of the liposomes to PMN leukocytes at 37°C but not at 0°C. Under identical conditions, no such enhanced binding of the liposomes was observed with erythrocytes and lymphocytes. These results demon‐strate that grafting of tuftsin on the liposome bilayer enables the liposome to recognize specifically the PMN leukocytes and to deliver its contents to these cells.