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Human glucagon‐like peptides 1 and 2 activate rat brain adenylate cyclase
Author(s) -
Hoosein Naseema M.,
Gurd Ruth S.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81245-4
Subject(s) - cyclase , glucagon , adenylate kinase , endocrinology , medicine , stimulation , chemistry , biology , biochemistry , hormone , receptor
Two human glucagon‐like peptides, GLP‐1 and GLP‐2, which are coencoded with pancreatic glucagon in the preproglucagon gene, do not significantly inhibit [ 125 I]monoiodoglucagon binding to rat liver and brain membranes and do not activate adenylate cyclase in liver plasma membranes. Nevertheless, GLP‐1 and GLP‐2 were each found to be potent stimulators of both rat hypothalamic and pituitary adenylate cyclase. Only 30–50 pM concentrations of each peptide elicited half‐maximal adenylate cyclase stimulation. Our data suggest that GLP‐1 and GLP‐2 may be neurotransmitters and/or neuroendocrine effectors, which would account for their high degree of sequence conservation through vertebrate evolution.