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Does the complex of aminoacyl‐tRNA synthetases and tRNA‐modifying enzymes prevent miscoding?
Author(s) -
Ryazanov A.G.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81228-4
Subject(s) - transfer rna , aminoacyl trna synthetase , enzyme , biochemistry , biology , aminoacyl trna , amino acyl trna synthetases , chemistry , rna , gene
Several aminoacyl‐tRNA synthetases of higher eukaryotes have always been found as multienzyme complexes. There are indications that these complexes can be associated with some tRNA‐modifying enzymes. The function of such complexes is unclear. I have noticed that 6 out of 7 aminoacyl‐tRNA synthetases most commonly occurring in complexes correspond to a group of tRNAs which must always contain a modified U in the first position of their anticodons. A hypothesis is proposed according to which association of 6 aminoacyl‐tRNA synthetases with U‐modifying enzymes can protect a cell from miscoding.