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Inositol trisphosphate activates pyruvate dehydrogenase in isolated fat cells
Author(s) -
Koepfer-Hobelsberger B.,
Wieland O.H.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81208-9
Subject(s) - inositol , pyruvate dehydrogenase complex , biochemistry , inositol trisphosphate receptor , chemistry , intracellular , inositol trisphosphate , mediator , biology , microbiology and biotechnology , enzyme , receptor
Inositol trisphosphate, when added to permeabilized rat fat cells, led to a several‐fold increase of pyruvate dehydrogenase activity due to conversion of the inactive phospho form (PDHb) to the active, dephospho form (PDHa). It is suggested that inositol trisphosphate, probably through intracellular Ca 2+ ‐mobilisation, acts as a physiological mediator of insulin for activation of the mitochondrial PDH‐complex.