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The decarboxylation of 3‐mercaptopyruvate to 2‐mercaptoacetate
Author(s) -
Mårtensson Johannes,
Nilsson Lennart,
Sörbo Bo
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81191-6
Subject(s) - decarboxylation , chemistry , oxidative decarboxylation , nad+ kinase , biochemistry , pyrophosphate , hydrolysis , thiamine pyrophosphate , cofactor , stereochemistry , coenzyme a , mitochondrion , enzyme , catalysis , reductase
Rat brain mitochondria were found to convert 3‐mercaptopyruvate to 2‐mercaptoacetate in the presence of NAD + coenzyme A and thiamin pyrophosphate. The overall reaction probably consists of an oxidative decarboxylation of 3‐mercaptopyruvate with 2‐mercaptoacetyl CoA as a product which is then hydrolyzed to 2‐mercaptoacetate by acyl CoA hydrolase