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Chaotic dynamics in yeast glycolysis under periodic substrate input flux
Author(s) -
Markus Mario,
Kuschmitz Dietrich,
Hess Benno
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81132-1
Subject(s) - aperiodic graph , entrainment (biomusicology) , phosphofructokinase , chaotic , pyruvate kinase , flux (metallurgy) , saccharomyces cerevisiae , yeast , biological system , substrate (aquarium) , biophysics , glycolysis , physics , chemistry , biochemistry , biology , enzyme , mathematics , computer science , rhythm , combinatorics , ecology , organic chemistry , artificial intelligence , acoustics
The numerical analysis for a glycolytic model containing the enzymes phosphofructokinase and pyruvate kinase reveals different types of entrainment, as well as chaotic response under sinusoidal substrate input. Entrainment with response periods 1, 2, 3, 5 and 7‐times the input flux period and aperiodic behaviour is verified by measurements of NADH fluorescence in extracts of Saccharomyces cerevisiae in the theoretically predicted range. The stroboscopic transfer function obtained from the aperiodic signal admits period 3, implying chaos according to the Li‐Yorke theorem.