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Hydroxyl radical production and DNA damage induced by anthracycline‐iron complex
Author(s) -
Muindi Josephia R.F.,
Sinha Birandra K.,
Gianni Luca,
Myers Charles E.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81130-8
Subject(s) - hydroxyl radical , radical , chemistry , ternary complex , hydrogen peroxide , dna , dna damage , reactive oxygen species , decomposition , peroxide , cleave , photochemistry , biochemistry , organic chemistry , enzyme
Adriamycin‐Fe 3+ complex catalyzes the formation of hydroxyl radical from hydrogen peroxide but the DNA‐adriamycin‐iron ternary complex is much more effective. 11‐Deoxyadriamycin, which shows no spectral evidence of complex formation with iron, was ineffective. The generation of hydroxyl radical by adriamycin‐Fe 3+ complex in the presence of DNA correlates with its ability to cleave DNA. Hydroxyl radicals are thus implicated as the reactive oxygen species involved in the DNA damage caused by the adriamycin‐Fe 3+ complex.