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Sugar moiety of cardiac glycosides is essential for the inhibitory action on the palytoxin‐induced K + release from red blood cells
Author(s) -
Ozaki Hiroshi,
Nagase Hiromi,
Urakawa Norimoto
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81045-5
Subject(s) - palytoxin , glycoside , moiety , chemistry , inhibitory postsynaptic potential , stereochemistry , sugar , red blood cell , cardiac glycoside , biochemistry , organic chemistry , biology , toxin , endocrinology , ouabain , sodium
Palytoxin (PTX), a highly toxic and sugar‐containing substance isolated from Palythoa tuberculosa , caused K + release from rabbit red blood cells. Cardiac glycosides, such as ouabain, convallatoxin, cymarin, digoxin and digitoxin, inhibited the PTX‐induced K + release. Their corresponding aglycones did not inhibit the K + release, but antagonized the inhibitory effect of the glycosides. All these cardiotonic steroids equally inhibited the activity of (Na + + K + ‐ATPase prepared from hog cerebral cortex. These results suggest that the sugar moiety of the cardiac glycosides is important for the inhibitory effect on the K + release induced by PTX and that the inhibition is not related to their inhibitory potency on the (Na + + K + )‐ATPase activity.