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The binding of Gla‐containing proteins to phospholipids
Author(s) -
Vermeer Cees
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81040-6
Subject(s) - osteocalcin , phospholipid , chemistry , coagulation , vesicle , biochemistry , matrix gla protein , alkaline phosphatase , phosphate , medicine , enzyme , membrane , hyperphosphatemia
It is demonstrated here that osteocalcin, the Gla‐containing protein from bone, is unable to interfere with the binding of the blood coagulation factors to phospholipid vesicles. Therefore, it seems that besides the Gla residues other structural features of the coagulation factors are required for their effective binding to phospholipid surfaces.