Premium
Tetraglycylferrichrome ‐ the first heptapeptide ferrichrome
Author(s) -
Deml G.,
Voges K.,
Jung G.,
Winkelmann G.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81016-9
Subject(s) - ferrichrome , neurospora crassa , neurospora , stereochemistry , residue (chemistry) , biology , biochemistry , peptide , chemistry , escherichia coli , bacterial outer membrane , mutant , gene
From a strain of Neovossia indien (Mitra) Mundk., a smut fungus of the order Tilletiales, a novel ferrichrome‐type siderophore was isolated. We have demonstrated that this is a heptapeptide rather than the usual hexapeptide, which contained, in addition to L‐ornithine, a (Gly) 4 sequence instead of the (Gly) 3 sequence usually found. Transport studies with 55 Fe‐labelled (Gly) 4 ‐ferrichrome and (Gly) 3 ‐ferrichrome in Neurospora crassa revealed identical uptake rates, indicating that increased ring size and conformational flexibility of the peptide backbone are of minor importance during function and recognition by the ferrichrome transport system.