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Hb Okazaki [β93(F8) Cys → Arg], a new hemoglobin variant with increased oxygen affinity and instability
Author(s) -
Harano Keiko,
Harano Teruo,
Shibata Susumu,
Ueda Satoshi,
Mori Hiroo,
Seki Masami
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81014-5
Subject(s) - okazaki fragments , hemoglobin , chemistry , beta (programming language) , oxygen , biochemistry , tyrosine , amino acid , dna , organic chemistry , eukaryotic dna replication , dna repair , computer science , programming language
A new abnormal hemoglobin, Hb Okazaki [β93(F9) Cys → Arg], with an amino acid substitution at the tyrosine pocket of the β chain as well as at the α 2 β 1 contact of the quaternary structure of molecule, was discovered in a Japanese man. This hemoglobin showed increased oxygen affinity and molecular instability.