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Reduction of daunorubicin aqueous solutions by COO .− free radicals
Author(s) -
Houée-Levin C.,
Gardès-Albert M.,
Ferradini C.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81010-8
Subject(s) - daunorubicin , radiolysis , radical , aqueous solution , chemistry , hydroquinone , bond cleavage , cleavage (geology) , photochemistry , radiochemistry , organic chemistry , catalysis , materials science , medicine , leukemia , fracture (geology) , composite material
Daunorubicin aqueous solutions were reduced by COO − free radicals produced by γ‐radiolysis. This reaction leads to 7‐deoxyaglycon daunomycinone. Added before irradiation, H 2 O 2 oxidizes hydroquinone daunorubicin giving back the drug directly and thus preventing C‐O bond cleavage. The implications of this reaction on the mechanism of the reductive cleavage are discussed.