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The anomalous effect of some ACTH‐fragments missing the amino acid sequence 1–10 on the corticosteroidogenesis in purified isolated rat adrenal cells
Author(s) -
Goverde H.J.M.,
Smals A.G.H.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81009-1
Subject(s) - adrenocorticotropic hormone , potency , chemistry , peptide , biological activity , endocrinology , medicine , peptide hormone , in vitro , biochemistry , biology , hormone
The corticosteroidogenicity of ACTH‐derived peptides was tested in a purified isolated rat adrenal cell system. The activity was related to the activity of standard ACTH (synthetic hACTH 1–39 ; potency fixed at 100). The peptides ACTH 11–19 NH 2 and ACTH 11–24 showed steroidogenicity at pharmacological doses (potencies: 0.00067 and 0.00032, respectively). None of the peptides tested inhibited or potentiated the ACTH‐induced steroidogenesis at low doses (0.5–50 000 pg). The results suggest the presence of a second center within the ACTH molecule capable of inducing steroidogenesis.