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Is the induction of neuroblastoma differentiation by CCA mediated by its effects on the electrochemical gradient?
Author(s) -
Vayssière J.L.,
Berthelot F.,
Gros F.,
Croizat B.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)81008-x
Subject(s) - chemistry , neuroblastoma , electrochemistry , cancer research , medicine , biology , genetics , cell culture , electrode
Various mitochondrial inhibitors are tested in neuroblastoma cells. Their effects on the mit‐proteins and some cytoskeletal proteins are compared to those of CCA, a differentiation inducer. This comparison favours the hypothesis that the primary effect of CCA induction is an alteration of the electrochemical gradient.