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Regulation of neuropeptide Y (NPY) binding by guanine nucleotides in the rat cerebral cortex
Author(s) -
Undén Anders,
Bartfai Tamas
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80995-3
Subject(s) - neuropeptide y receptor , gtp' , medicine , dissociation constant , endocrinology , chemistry , nucleotide , guanine , receptor , neuropeptide , biology , biochemistry , enzyme , gene
In the presence of GTP, GDP, GMPP(NH)P, GMPP(CH 2 )P, GMPP(S)P but not in the presence of GMP, cGMP or ATP, the high affinity binding of neuropeptide Y (NPY) was reduced in a dose‐dependent manner. GTP (0.1 mM) diminished the maximal binding capacity for 125 I‐labelled NPY by 40% without any change in the equilibrium dissociation constant of the receptor 125 I‐labelled NPY complex.