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The catabolite gene activation system of E.coli may be directly involved in regulation of bacteriophage λ development
Author(s) -
Glukhov I.L.,
Fodor I.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80993-x
Subject(s) - lysogenic cycle , bacteriophage , catabolite repression , lytic cycle , gene , prophage , biology , escherichia coli , lambda phage , dna binding protein , microbiology and biotechnology , genetics , chemistry , virus , mutant , transcription factor
The primary structure of bacteriophage λ DNA has been searched for the presence of consensus CAP binding sites. Four putative CAP binding sites have been found on the λ genome, indicating that the catabolite gene activation system of E.coli may be directly involved in the regulation of λ development. Molecular mechanisms of putative cAMP‐CAP‐mediated stimulation of lysogenic and lytic responses are discussed.