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Xanthine oxidase induced depolymerization of hyaluronic acid in the presence of ferritin
Author(s) -
Carlin Gunnar,
Djursater Richard
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80974-6
Subject(s) - radical , hyaluronic acid , chemistry , xanthine oxidase , depolymerization , ferritin , biochemistry , oxidase test , oxygen , reactive oxygen species , xanthine , enzyme , polymer chemistry , organic chemistry , biology , genetics
Oxygen free radicals generated by xanthine oxidase are able to depolymerize hyaluronic acid in the presence of ferritin‐bound iron. This suggests that ferritin can catalyse the Haber‐Weiss reaction, leading to the formation of highly damaging hydroxyl radicals.